Certified Ophthalmic Medical Technologist (COMT) Practice Exam

In what condition is edrophonium chloride generally administered?

1. Glaucoma treatment

2. Myasthenia gravis diagnosis

3. Hypotension management

4. Cataract surgery preparation

The correct answer is: Myasthenia gravis diagnosis

Edrophonium chloride is primarily administered for the diagnosis of myasthenia gravis. This condition is an autoimmune disorder characterized by weakness in the skeletal muscles due to a reduction in acetylcholine receptors at the neuromuscular junction. Edrophonium chloride acts as a short-acting inhibitor of the enzyme acetylcholinesterase, which breaks down acetylcholine. By inhibiting this enzyme, edrophonium increases the availability of acetylcholine at the neuromuscular junction, temporarily improving muscle strength in individuals with myasthenia gravis. This response helps clinicians confirm the diagnosis of the condition. The other mentioned conditions either do not involve the use of edrophonium chloride or are not relevant to its pharmacological action, which is specifically tailored for the neuromuscular junction and acetylcholine dynamics.