Certified Ophthalmic Medical Technologist (COMT) Practice Exam 2026 – Comprehensive All-in-One Guide to Success

Bull's eye maculopathy is a characteristic retinal finding associated with the use of Plaquenil (hydroxychloroquine), which is commonly prescribed for conditions like rheumatoid arthritis and lupus. This condition is known to cause specific changes in the macula, resulting in a distinct pattern of parafoveal retinal pigmentary changes. These changes typically manifest as a 'bull's eye' appearance due to the loss of retinal pigment epithelium (RPE) and the accumulation of pigment at the fovea. This finding is a direct consequence of the drug's toxicity to the retinal cells, particularly after prolonged exposure or at higher doses.

Early detection of bull's eye maculopathy is crucial since it can lead to permanent vision loss if not monitored and managed properly. Regular eye examinations, including visual field tests and optical coherence tomography (OCT), are important for patients on hydroxychloroquine to monitor for this potential adverse effect, highlighting the significance of understanding this specific retinal finding in clinical practice.